Fantasy matchup analysis — how many points the Bills allow to quarterbacks. Updated through the 2025 season. Use this to identify streamers and make start/sit decisions.
Players who have historically scored most against the Buffalo Bills defense:
Last 10 games quarterbacks faced the Buffalo Bills (2024–2025 seasons):
| Game | Player | Fantasy Pts |
|---|---|---|
| S2025 Wk18 | Brady Cook NYJ |
9.1 |
| S2025 Wk17 | Jalen Hurts PHI |
8.9 |
| S2025 Wk16 | Shedeur Sanders CLE |
13.2 |
| S2025 Wk15 | Drake Maye NE |
21.5 |
| S2025 Wk14 | Joe Burrow CIN |
25.4 |
| S2025 Wk13 | Aaron Rodgers PIT |
2.7 |
| S2025 Wk12 | Davis Mills HOU |
14.5 |
| S2025 Wk11 | Baker Mayfield TB |
17.8 |
| S2025 Wk9 | Patrick Mahomes KC |
11.5 |
| S2025 Wk6 | Michael Penix ATL |
14.6 |
This is matchup context, not a personalized recommendation. Connect your Sleeper, ESPN, or Yahoo league and PlayCaller's AI gives you a start/sit decision based on your exact roster, league scoring, and this week's matchup.
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