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Buffalo Bills Defense vs Flex (RB/WR/TE)

Fantasy matchup analysis — how many points the Bills allow to flex (rb/wr/te). Updated through the 2025 season. Use this to identify streamers and make start/sit decisions.

9.2
Avg fantasy pts allowed per game to flex (rb/wr/te)
#1 Easiest (Top 5)
NFL defense ranking vs FLEX
238
Games in sample (2024–2025)

Top Targets vs Bills

Players who have historically scored most against the Buffalo Bills defense:

#1 Target 🎯
Derrick Henry
BAL
32.6
avg pts vs Bills (2 games)
#2 Target
De'Von Achane
MIA
29.6
avg pts vs Bills (4 games)
#3 Target
TreVeyon Henderson
NE
17.4
avg pts vs Bills (2 games)

Recent Game Log

Last 10 games flex (rb/wr/te) faced the Buffalo Bills (2024–2025 seasons):

GamePlayerFantasy Pts
S2025 Wk18 Quentin Skinner
NYJ
 2
S2025 Wk18 Isaiah Williams
NYJ
 7.4
S2025 Wk18 Khalil Herbert
UNK
 5.6
S2025 Wk18 Tim Patrick
NYJ
 1.4
S2025 Wk18 Andrew Beck
NYJ
 7.2
S2025 Wk18 Isaiah Williams
NYJ
 7.4
S2025 Wk18 Jelani Woods
NYJ
 2
S2025 Wk18 Kene Nwangwu
NYJ
 1.8
S2025 Wk17 A.J. Brown
PHI
 11.8
S2025 Wk17 Darius Cooper
PHI
 1.4

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Frequently Asked Questions

Is the Buffalo Bills defense good or bad for fantasy flex (rb/wr/te)?
The Buffalo Bills allow an average of 9.2 fantasy points per game to flex (rb/wr/te), ranking #1 Easiest (Top 5) among all NFL defenses (238 games sampled, 2024–2025 seasons).
Which flex (rb/wr/te) should I start against the Buffalo Bills?
Historically, flex (rb/wr/te) who have scored most against the Buffalo Bills: Derrick Henry (32.6 avg pts in 2 games), De'Von Achane (29.6 avg pts in 4 games), TreVeyon Henderson (17.4 avg pts in 2 games). Connect your league to PlayCaller for a roster-specific verdict.
How do I use defense vs position data in fantasy football?
Defense vs position (DVP) data shows how many fantasy points a team has historically allowed to a specific position. High avg pts allowed = easy matchup. Low avg pts allowed = tough matchup. Use it as a tiebreaker when deciding between two similarly-ranked players with different matchups.

Other positions vs Bills

Running BacksWide ReceiversTight EndsQuarterbacksKickers

NFL position rankings

RB Rankings WR Rankings TE Rankings QB Rankings