Fantasy matchup analysis — how many points the 49ers allow to flex (rb/wr/te). Updated through the 2025 season. Use this to identify streamers and make start/sit decisions.
Players who have historically scored most against the San Francisco 49ers defense:
Last 10 games flex (rb/wr/te) faced the San Francisco 49ers (2024–2025 seasons):
| Game | Player | Fantasy Pts |
|---|---|---|
| S2025 Wk18 | Zach Charbonnet SEA |
18.7 |
| S2025 Wk18 | AJ Barner SEA |
3.4 |
| S2025 Wk18 | Eric Saubert SEA |
3 |
| S2025 Wk18 | Rashid Shaheed SEA |
1.2 |
| S2025 Wk18 | Jaxon Smith-Njigba SEA |
14.4 |
| S2025 Wk18 | Cooper Kupp SEA |
4.9 |
| S2025 Wk18 | Emanuel Wilson SEA |
5.8 |
| S2025 Wk17 | D'Andre Swift CHI |
21.9 |
| S2025 Wk17 | Colston Loveland CHI |
21.4 |
| S2025 Wk17 | Cole Kmet CHI |
3.6 |
This is matchup context, not a personalized recommendation. Connect your Sleeper, ESPN, or Yahoo league and PlayCaller's AI gives you a start/sit decision based on your exact roster, league scoring, and this week's matchup.
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