Fantasy matchup analysis — how many points the 49ers allow to running backs. Updated through the 2025 season. Use this to identify streamers and make start/sit decisions.
Players who have historically scored most against the San Francisco 49ers defense:
Last 10 games running backs faced the San Francisco 49ers (2024–2025 seasons):
| Game | Player | Fantasy Pts |
|---|---|---|
| S2025 Wk18 | Zach Charbonnet SEA |
18.7 |
| S2025 Wk18 | Emanuel Wilson SEA |
5.8 |
| S2025 Wk17 | Kyle Monangai CHI |
7.7 |
| S2025 Wk17 | D'Andre Swift CHI |
21.9 |
| S2025 Wk16 | Jonathan Taylor IND |
16.9 |
| S2025 Wk15 | Michael Carter TEN |
13.4 |
| S2025 Wk15 | Tyjae Spears TEN |
5.6 |
| S2025 Wk15 | Michael Carter TEN |
13.4 |
| S2025 Wk15 | Tony Pollard TEN |
18.2 |
| S2025 Wk13 | Dylan Sampson CLE |
2.3 |
This is matchup context, not a personalized recommendation. Connect your Sleeper, ESPN, or Yahoo league and PlayCaller's AI gives you a start/sit decision based on your exact roster, league scoring, and this week's matchup.
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