Fantasy matchup analysis — how many points the 49ers allow to quarterbacks. Updated through the 2025 season. Use this to identify streamers and make start/sit decisions.
Players who have historically scored most against the San Francisco 49ers defense:
Last 10 games quarterbacks faced the San Francisco 49ers (2024–2025 seasons):
| Game | Player | Fantasy Pts |
|---|---|---|
| S2025 Wk18 | Sam Darnold SEA |
8.8 |
| S2025 Wk17 | Caleb Williams CHI |
23 |
| S2025 Wk16 | Philip Rivers UNK |
18.1 |
| S2025 Wk15 | Cam Ward TEN |
15 |
| S2025 Wk13 | Shedeur Sanders CLE |
10.6 |
| S2025 Wk12 | Bryce Young CAR |
10.3 |
| S2025 Wk11 | Jacoby Brissett ARI |
23.9 |
| S2025 Wk10 | Matthew Stafford LAR |
26.9 |
| S2025 Wk9 | Jaxson Dart NYG |
27.2 |
| S2025 Wk8 | C.J. Stroud HOU |
22.7 |
This is matchup context, not a personalized recommendation. Connect your Sleeper, ESPN, or Yahoo league and PlayCaller's AI gives you a start/sit decision based on your exact roster, league scoring, and this week's matchup.
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