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NFL Waiver Wire Week 16 2025 — AI-Powered Pickup Targets

WEEK 16 · 2025 May 28, 2026

Week 16 Waiver Wire: Pickups to Win Your Championship

The fantasy playoffs are here, and roster construction has never mattered more. With several high-profile injuries and depth chart shakeups reshaping fantasy landscapes heading into the most important weeks of the season, the waiver wire is more relevant than ever. Our PlayCaller beat reporters have been tracking the signals closely, and there are some genuinely actionable names available in most leagues right now. Here is who you should be targeting before Tuesday's wire clears.

Tua Tagovailoa, QB, Atlanta Falcons

Tagovailoa is locked in a legitimate quarterback competition with a banged-up Michael Penix in Atlanta, and that situation carries enormous fantasy upside. Penix's knee injury is being monitored closely, and if Tua wins the starting job, he inherits a weapons-rich offense featuring Kyle Pitts, who just posted an 88-928-5 season. Tua is a must-add in two-QB leagues and worth a speculative pickup in singles leagues given Penix's uncertain health.

Jeremiyah Love, RB, Arizona Cardinals

Love projects as Arizona's featured back moving forward, bringing genuine big-play ability as both a runner and a receiver out of the backfield. The Cardinals' backfield is technically crowded, but PlayCaller's beat reporters flagged Love as the clear focal point of that committee based on his role expansion signal. With Trey Benson essentially on his way out of town via trade, Love's path to meaningful work gets cleaner by the week. Scoop him up while his ownership is still low.

Kyle Pitts, TE, Atlanta Falcons

Pitts is locked in at $15 million and coming off a legitimate bounce-back year. His value is tied to the Atlanta quarterback battle, but in either scenario, a tight end with his receiving ability is going to see targets. If Tua wins the job and re-establishes the chemistry they showed together previously, Pitts becomes a top-five fantasy tight end. He is worth rostering now before the QB situation resolves itself.

Jayden Daniels, QB, Washington Commanders

Daniels is working his way back from injury, and his coaching staff is speaking glowingly about his sharpness in practice. Commander coach Dan Quinn specifically highlighted his mental quickness upon return, which is exactly the kind of green flag fantasy managers want to hear. Daniels was a QB1 before going down, and if he is trending toward a full workload by Week 16 he is a streaming option with legitimate upside given Washington's offensive scheme.

Brian Robinson Jr., RB, Atlanta Falcons

Robinson just landed in Atlanta as Bijan Robinson's primary backup. While a handcuff role is not thrilling, Bijan's injury history is real and Brian Robinson proved in San Francisco that he can handle a full workload when called upon. In deeper leagues, he is a fine stash with legitimate upside if Bijan misses any time down the stretch.

Zachariah Branch, WR, Atlanta Falcons

Branch arrives in Atlanta after a strong college season and brings slot and gadget value right away. Keep in mind there is some off-field risk after a misdemeanor arrest over the weekend, so hold off in leagues with conduct policies. But from a pure football standpoint, a young receiver with return ability and a role in a pass-heavy offense is worth a late waiver claim in deeper formats.

Good luck in your championship run. Check PlayCaller throughout the week as injury designations roll in and the picture gets clearer before Sunday's slate.

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