NFL · Week 6 · 2026 Fantasy Preview

BUF at LV — Fantasy Preview

Top targets, injury updates, and defense vs position matchup data for Week 6 of the 2026 NFL season.

BUF
BUF · Away
@
LV
LV · Home
Sunday, October 18, 2026
4:25 PM EDT

Fantasy Targets by Team

BUF Targets
Josh Allen QB · BUF
Opp allows 15.3 pts/game to QB (#1 easiest)
23.7
avg pts (32g)
Josh Allen QB · BUF
Opp allows 15.3 pts/game to QB (#1 easiest)
23.7
avg pts (32g)
James Cook RB · BUF
Opp allows 9 pts/game to RB (#2 easiest)
17.2
avg pts (33g)
DJ Moore WR · BUF
Opp allows 8.8 pts/game to WR (#3 easiest)
12.7
avg pts (32g)
DJ Moore WR · BUF
Opp allows 8.8 pts/game to WR (#3 easiest)
12.7
avg pts (32g)
LV Targets
Brock Bowers TE · LV
Opp allows 5.8 pts/game to TE (#4 easiest)
15.1
avg pts (29g)
Ashton Jeanty RB · LV
Opp allows 11.3 pts/game to RB (#2 easiest)
14.4
avg pts (17g)
Kirk Cousins QB · LV
Opp allows 14.4 pts/game to QB (#1 easiest)
12.5
avg pts (24g)
Aidan O'Connell QB · LV
Opp allows 14.4 pts/game to QB (#1 easiest)
10.2
avg pts (10g)
Tre Tucker WR · LV
Opp allows 9.2 pts/game to WR (#3 easiest)
9.1
avg pts (32g)

Injury & Beat Reporter Signals

BUF
medium DJ Moore role expansion
Moore was traded to Buffalo from Chicago for a 2nd-round pick to provide Josh Allen a proven No. 1 receiver. He faces le…
medium Khalil Shakir role reduction
Shakir led Bills with 95 targets in 2025 (72-719-4), but DJ Moore's acquisition as the top WR target should reduce his v…
medium Josh Allen return from injury
Allen suffered a fifth metatarsal fracture in his right foot post-Week 16 and underwent surgery with 8-10 week recovery …
medium Dalton Kincaid return from injury
Kincaid avoided offseason surgery for his PCL injury and reports feeling excellent heading into 2026. He should maintain…
medium Khalil Shakir role reduction
After leading the Bills with 95 targets in 2025, Shakir will see reduced volume as Josh Allen's primary target with DJ M…
medium DJ Moore role expansion
The 29-year-old veteran was acquired from Chicago for a second-round pick to provide Josh Allen a proven No. 1 receiver.…
LV

No active signals

Defense vs Position Matchup

BUF defense — pts allowed
QB 14.4 avg pts
RB 11.3 avg pts
WR 9.2 avg pts
TE 5.8 avg pts
LV defense — pts allowed
QB 15.3 avg pts
RB 9 avg pts
WR 8.8 avg pts
TE 6.7 avg pts

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Frequently Asked Questions

Who should I start from the BUF vs LV game?
Top fantasy targets in this matchup: Josh Allen and Brock Bowers. See the full target list and injury updates above.
Is this a good DFS game for Week 6?
Check back closer to game time for spread, total, and projected scoring environment data. Use the player targets above to identify DFS value plays.
What is the fantasy matchup outlook for BUF players this week?
LV defense allows 9 pts/game to RBs and 8.8 pts/game to WRs. Historical matchup data above shows which positions are most exploitable.

More Week 6 matchup analysis

← Week 5 RB Rankings WR Rankings QB Rankings