NFL · Week 5 · 2026 Fantasy Preview

BUF at LAR — Fantasy Preview

Top targets, injury updates, and defense vs position matchup data for Week 5 of the 2026 NFL season.

BUF

BUF · Away

LAR

LAR · Home

Tuesday, October 13, 2026

8:15 PM EDT

Fantasy Targets by Team

BUF Targets

Josh Allen QB · BUF

Opp allows 16.4 pts/game to QB (#1 easiest)

23.7

avg pts (32g)

Josh Allen QB · BUF

Opp allows 16.4 pts/game to QB (#1 easiest)

23.7

avg pts (32g)

James Cook RB · BUF

Opp allows 10.8 pts/game to RB (#2 easiest)

17.2

avg pts (33g)

DJ Moore WR · BUF

Opp allows 10.1 pts/game to WR (#3 easiest)

12.7

avg pts (32g)

DJ Moore WR · BUF

Opp allows 10.1 pts/game to WR (#3 easiest)

12.7

avg pts (32g)

LAR Targets

Puka Nacua WR · LAR

Opp allows 9.2 pts/game to WR (#3 easiest)

21.5

avg pts (27g)

Matthew Stafford QB · LAR

Opp allows 14.4 pts/game to QB (#1 easiest)

17.6

avg pts (33g)

Davante Adams WR · LAR

Opp allows 9.2 pts/game to WR (#3 easiest)

16.6

avg pts (28g)

Kyren Williams RB · LAR

Opp allows 11.3 pts/game to RB (#2 easiest)

16.2

avg pts (33g)

Tyler Higbee TE · LAR

Opp allows 5.8 pts/game to TE (#4 easiest)

8.9

avg pts (11g)

Injury & Beat Reporter Signals

BUF

medium DJ Moore role expansion

Moore was traded to Buffalo from Chicago for a 2nd-round pick to provide Josh Allen a proven No. 1 receiver. He faces le…

medium Khalil Shakir role reduction

Shakir led Bills with 95 targets in 2025 (72-719-4), but DJ Moore's acquisition as the top WR target should reduce his v…

medium Josh Allen return from injury

Allen suffered a fifth metatarsal fracture in his right foot post-Week 16 and underwent surgery with 8-10 week recovery …

medium Dalton Kincaid return from injury

Kincaid avoided offseason surgery for his PCL injury and reports feeling excellent heading into 2026. He should maintain…

medium Khalil Shakir role reduction

After leading the Bills with 95 targets in 2025, Shakir will see reduced volume as Josh Allen's primary target with DJ M…

medium DJ Moore role expansion

The 29-year-old veteran was acquired from Chicago for a second-round pick to provide Josh Allen a proven No. 1 receiver.…

LAR

No active signals

Defense vs Position Matchup

BUF defense — pts allowed

QB 14.4 avg pts

RB 11.3 avg pts

WR 9.2 avg pts

TE 5.8 avg pts

LAR defense — pts allowed

QB 16.4 avg pts

RB 10.8 avg pts

WR 10.1 avg pts

TE 8.5 avg pts

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Frequently Asked Questions

Who should I start from the BUF vs LAR game?

Top fantasy targets in this matchup: Josh Allen and Puka Nacua. See the full target list and injury updates above.

Is this a good DFS game for Week 5?

Check back closer to game time for spread, total, and projected scoring environment data. Use the player targets above to identify DFS value plays.

What is the fantasy matchup outlook for BUF players this week?

LAR defense allows 10.8 pts/game to RBs and 10.1 pts/game to WRs. Historical matchup data above shows which positions are most exploitable.

More Week 5 matchup analysis

← Week 4 RB Rankings WR Rankings QB Rankings