NFL · Week 4 · 2026 Fantasy Preview
DEN at SF — Fantasy Preview
Top targets, injury updates, and defense vs position matchup data for Week 4 of the 2026 NFL season.
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Frequently Asked Questions
Who should I start from the DEN vs SF game?
Top fantasy targets in this matchup: Bo Nix and Christian McCaffrey. See the full target list and injury updates above.
Is this a good DFS game for Week 4?
Check back closer to game time for spread, total, and projected scoring environment data. Use the player targets above to identify DFS value plays.
What is the fantasy matchup outlook for DEN players this week?
SF defense allows 10.8 pts/game to RBs and 9.3 pts/game to WRs. Historical matchup data above shows which positions are most exploitable.