Updated Tuesday, November 10, 3:17 AM EST with injury designations as of that time.
This week's slate has several favorable matchups against defenses that have struggled to contain certain positions. It also has a handful of spots where recent usage or a tough opponent makes the case for a different option.
Week 10 starts
Drake Maye (NE) at DET
21.1 PPR points per game this season, 24.1 over his last 3. DET allows 22.5 PPR points per game to QBs, the most in the league. 93.7% of snaps over the last 3. Confidence: 66%.
Maye has been trending up, and he faces the defense that gives up more PPR points to quarterbacks than any other in the league. Playing nearly every snap lately, he is in a strong spot to keep climbing.
Trevor Lawrence (JAX) at TEN
18.9 PPR points per game this season, 20.4 over his last 3. TEN allows 19.4 PPR points per game to QBs, 5th most. 93.7% of snaps over the last 3. Confidence: 42%.
Lawrence heads into a matchup where the opposing defense has been generous to quarterbacks, ranking 5th most in points allowed. His recent scoring is a bit above his season pace, which fits a starter's profile for this week.
Braelon Allen (NYJ) vs BUF
11.7 PPR points per game this season, 16 over his last 3. BUF allows 24.7 PPR points per game to RBs, 5th most. 12.3% target share over the last 3. Confidence: 60%.
Allen's last three games have outpaced his season average, and Buffalo has been one of the friendlier defenses for running backs. A steady target share gives him another way to earn points beyond the ground game.
Jakobi Meyers (JAX) at TEN
9.5 PPR points per game this season, 9.4 over his last 3. TEN allows 38.6 PPR points per game to WRs, the most in the league. 23.3% target share over the last 3. Confidence: 45%.
Meyers draws a Tennessee defense that has given up the most PPR points to wide receivers. With nearly a quarter of the targets lately, he is positioned to see enough looks to take advantage.
Jameson Williams (DET) vs NE
13.2 PPR points per game this season, 16 over his last 3. NE allows 38.4 PPR points per game to WRs, 2nd most. 20.3% target share over the last 3. Confidence: 42%.
Williams has been heating up, and he gets a New England defense that ranks 2nd most in points allowed to receivers. A fifth of the targets over the last 3 games keeps him involved enough to cash in.
Rashee Rice (KC) at ATL
13.2 PPR points per game this season, 14.7 over his last 3. ATL allows 37.5 PPR points per game to WRs, 3rd most. 33% target share over the last 3. Confidence: 55%.
Rice has been the focal point of the passing game, commanding a third of the targets recently. Atlanta has been among the softer defenses against wide receivers, which suits that heavy volume well.
Tyler Warren (IND) vs MIA
12 PPR points per game this season, 11.9 over his last 3. MIA allows 15.7 PPR points per game to TEs, 7th most. 32.7% target share over the last 3. Confidence: 54%.
Warren has been a central piece of the Indianapolis passing attack with a big slice of the targets. Miami has leaked production to tight ends, so the role and the matchup both point toward a solid outing.
Week 10 sits
Bryce Young (CAR) at NO
19.1 PPR points per game this season, 13.4 over his last 3. NO allows 17.8 PPR points per game to QBs, 15th most. 92.3% of snaps over the last 3. Confidence: 24%.
Young's recent scoring has dipped well below his season pace, and New Orleans is only a middling matchup for quarterbacks. With the downward trend, there are likely better options available.
Tony Pollard (TEN) vs JAX
14.6 PPR points per game this season, 24.3 over his last 3. JAX allows 16.7 PPR points per game to RBs, 2nd fewest. 9.7% target share over the last 3. Confidence: 26%.
Pollard has been scoring well lately, but Jacksonville has been one of the toughest defenses for running backs. A target share under 10% also limits his ways to produce if the ground game stalls.
Nico Collins (HOU) at CLE
15.3 PPR points per game this season, 9.7 over his last 3. CLE allows 29.3 PPR points per game to WRs, 13th fewest. 15% target share over the last 3. Confidence: 17%.
Collins has cooled off compared to his season pace, and the target share over his last 3 games is modest for a top option. Cleveland also gives up fewer points to receivers than most, so this is a spot to temper expectations.
Jalen Coker (CAR) at NO
12.3 PPR points per game this season, 6 over his last 3. NO allows 31.1 PPR points per game to WRs, 16th most. 16.3% target share over the last 3. Confidence: 22%.
Coker's production has dropped sharply over the last 3 games, falling to half his season average. A middling New Orleans matchup does little to offset that slide, so he is a risky play this week.
Sam LaPorta (DET) vs NE
11.6 PPR points per game this season, 5.5 over his last 3. NE allows 10.4 PPR points per game to TEs, 8th fewest. 15.7% target share over the last 3. Confidence: 23%.
LaPorta's recent scoring is well below his season average, and his share of the targets is modest. New England has been tough on tight ends, which makes this a difficult week to count on him.
Injury watch
Fantasy starters with an injury designation this week. Check again before kickoff.
| Player | Pos | Team | Status |
|---|---|---|---|
| Lamar Jackson | QB | BAL | IR |
| Rhamondre Stevenson | RB | NE | Out |
| Puka Nacua | WR | LAR | Questionable |
| Zay Flowers | WR | BAL | Questionable |
| Tyquan Thornton | WR | KC | IR |
| Garrett Wilson | WR | NYJ | Out |
| Michael Wilson | WR | ARI | Out |
| George Pickens | WR | DAL | Out |
| George Kittle | TE | SF | Questionable |
How these picks are made
Every name on this page is chosen by rules, not by hand. We take the fantasy-relevant players at each position by PPR points per game this season (at least 3 games). A start is a player outside the obvious every-week starters whose opponent is in the top 8 for PPR points allowed to his position, who has held his scoring over his last 3 games, and who isn't questionable. A sit is a usual starter facing a bottom-8 defense for his position, or whose scoring over his last 3 games has fallen well below his season average. These thresholds are heuristics.
Where a player shows a Confidence figure, it comes from our NFL confidence model, scored against this week's opponent using only games already played. The model is measured on held-out games (AUC 0.697 on the 2025 season); see its accuracy. A start needs a score of at least 30% and a sit at most 35% when the model has one. Injury designations come from the latest team reports and can change up to kickoff.